How It Works:

Amantadine belongs to the family of medications called antivirals. It works as an antiviral drug by blocking the reproduction of virus (viral replication) in the body. It also blocks activity of proteins called ‘NMDA glutamate receptors’ in the brain, thereby inhibiting the generation of abnormal movements of Parkinson’s disease.

Side Effects:

difficulty urinating or leaking of urine or uncontrollable wetting due to loss of bladder control ., shaking, rigid muscles, confusion or a feeling of being lost, blurred vision, elevation of mood, unable to sleep, light-headedness, a mottled purplish discoloration of the skin usually on the legs .Common: anxiety, loss of concentration, skin rashes due to herpes virus infection, vomiting, or muscle pain or weakness .Rare: defects in the clear covering of the eye called the cornea that affects clearness of vision, irregular heartbeats that one can feel, high fever, increased heart rate or blood pressure, muscle pain, abnormal mental condition in which a person gets thoughts that are not real, Very common: swelling of ankles, slurred speech, confusion, depression, urge to vomit, constipation, involuntary muscle contractions, loss of appetite, lose motions, sleepiness, uncontrolled shaking, nightmares, fits, low blood pressure that happens when you stand up from sitting or lying down, sweating .Uncommon: confusion, dry mouth, sweating more than usual, headache, nervousness, seeing and hearing things that are not really there, unsteady movement

Used For:

Amantadine is used to prevent and treat respiratory infection caused by influenza A virus. It is also used in treating abnormalities of movements such as uncontrolled shaking, slow movements, muscle stiffness associated with Parkinson’s disease or drug induced and in the treatment of severe and painful shingles (painful rashes usually in the form of a strip of blisters caused by herpes zoster virus).


  • Do not take amantadine, if you have fits (epilepsy); heart failure resulting in fluid build-up in the lungs, other body tissues or both (congestive heart failure); kidney or liver problems.
  • Avoid using amantadine, if you have ulcers in stomach or intestine; low blood pressure that may cause fainting; itchy skin rashes (eczema).
  • Do not take amantadine, if you have visual problems due to increased pressure in the eyes (glaucoma); history of mental problems including attempting suicide, confusion, seeing or hearing things that are not really there (hallucinations).
  • Avoid using amantadine, if you are addicted to any drug or alcohol.
  • Avoid consumption of alcohol while on treatment with amantadine.
  • Do not stop taking amantadine abruptly without consulting your doctor. It may cause worsening of Parkinson’s disease.
  • Do not stop taking amantadine abruptly without consulting your doctor if you are concurrently receiving medications for psychiatric problems (neuroleptics).
  • Use of amantadine may cause drowsiness, dizziness, fainting or blurring of vision that may affect your ability to drive or operate machines. Do not drive or operate machines till you feel better.
  • Do consult your doctor before taking amantadine if you are pregnant, planning to become pregnant or breastfeeding.

Frequently Ask Questions:

Q. Is amantadine an MAOI or an anticholinergic or an antibiotic or narcotic or stimulant or a dopamine agonist? Amantadine is not a MAOI or an anticholinergic or an antibiotic or narcotic or stimulant. It is an antiviral drug.
Q. Is amantadine available over the counter (OTC)?No, it is not available as OTC drug, consult your doctor before taking amantadine.
Q. Is amantadine like Adderall?No, amantadine is different than Adderall (amphetamine and dextroamphetamine). Adderall is a psychostimulant.
Q. Is amantadine a stimulant?No, amantadine is not a stimulant.
Q. Can I take ibuprofen (Advil) with amantadine?Ibuprofen (Advil) and amantadine should not to be taken together as they interact with each other. Please consult your doctor before taking other medicines along with amantadine.
Q. Can I take dextromethorphan (Dayquil) with amantadine?No results found for any interaction of dextromethorphan (Dayquil) with amantadine, but always consult with your doctor before taking this medication.
Q. Does amantadine help fatigue?Amantadine is sometimes effective in relieving fatigue in multiple sclerosis (a demyelinating disease marked by patches of hardened tissue in the brain or the spinal cord and associated especially with partial or complete paralysis and jerking muscle tremor).
Q. Does amantadine increase dopamine?Yes, amantadine is a dopaminergic drug, so it increases dopamine.
Q. Does amantadine work?Amantadine is a dopaminergic drug and an antiviral. If used to prevent viral infection it works by preventing the virus from reproducing, and in Parkinson’s disease it works by restoring the chemical balance between dopamine and acetylcholine (neuro-transmitters) in the brain.
Q. Does amantadine get you high/ hair loss / weight gain/ make you sleepy/ constipation/ high blood pressure?Amantadine has a common side effect of causing sleepiness. However, it is not known to cause constipation, high blood pressure, weight gain. If you experience such side effects, please consult your doctor.
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