Amphotericin B

How It Works:

Amphotericin B belongs to class of medications called polyene antimycotics. It acts on the outer covering (cell membrane) of the fungus resulting in leakage of essential nutrients from within the cells, thereby killing them.

Side Effects:

flushing, low blood magnesium level, low blood sodium level, nausea, high blood sugar, breathlessness, vomiting, Low blood potassium level, low blood pressure, chills and shivering., low blood calcium level, stomach pain, diarrhea, back pain, abnormal results for liver or kidney function showing up in blood tests or urine tests rash, fever, chest pain, faster heart rate, headache

Used For:

Amphotericin B is used in the treatment of serious fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells [neutrophils]) and Visceral leishmaniasis (disease caused by a parasite).

Instructions:

  • Before you take amphotericin B, inform your doctor if you suffer from diabetes, liver/kidney problem or are on dialysis or have low potassium level in blood.
  • You should monitor your condition through regular laboratory evaluation of potassium, magnesium as well as renal, hepatic and hematopoietic function.
  • Take precautions as amphotericin B may reduce the ability to drive or operate machinery.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently Ask Questions:

Q. Is amphotericin B safe during pregnancy?Amphotericin B can be used during pregnancy if the benefit to the mother outweighs the risk to the mother and infant. 
Q. Is it safe to use amphotericin B during breastfeeding?Amphotericin B should be given only if the potential benefit to the mother justifies the potential risk to the infant. 
Q. Is amphotericin B an antibiotic?Yes, amphotericin B is an antifungal antibiotic for the treatment of serious infections caused by fungi like fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells [neutrophils]) and Visceral leishmaniasis (disease caused by a parasite).
Q. Is amphotericin B fungistatic or fungicidal?Amphotericin B is fungicidal in nature, it acts by killing the fungus.
Q. Is amphotericin B testing dose needed?Yes, administration of amphotericin B is associated with allergy (severe and serious allergic) reaction, therefore it is recommended to administer a test dose before starting the therapy to check for sensitivity. 
Q. Is amphotericin B light sensitive?Amphotericin B is not light sensitive.
Q. How is amphotericin B administered?Amphotericin B is either administered as intravenous injection or infusion by a registered medical professional only.
Q. What is amphotericin B liposomal?Liposomal amphotericin B is a lipid-associated formulation. Liposomal encapsulation or incorporation into a lipid complex of amphotericin B can substantially improves drug safety especially nephrotoxicity associated with the drug.
Q. How does amphotericin B cause nephrotoxicity and hyperkalemia?Amphotericin B can disrupt the lipid components of human kidney cells, thereby causing nephrotoxicity. The exact mechanism of hypokalemia is not known, but kidney damage may result in excessive loss of potassium in urine.
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