Chlorpromazine

How It Works:

Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).

Side Effects:

tachycardia, skin pigmentation, blurred vision, allergic reactions, neuroleptic malignant syndrome, drowsiness, blood dyscrasias, acute dystonia, insomnia, temperature disorders, skin rashes, tachypnea, Seizures, constipation, hypothermia, ventricular arrhythmias, dizziness, diaphoresis, akathisia, dry mouth, headache, jaundice, weight gain, decrease in libido.

Used For:

Agitated states in the elderly, agitation, agitation and restlessness in the elderly, autism, childhood schizophrenia, conduct disorder with hyperactivity, control of agitated states in elderly without confusion, enhance permeation of SC or IM inj, hiccup due to gastric distension in palliative care, induction of labour, intractable hiccup, locally advanced or metastatic pancreatic cancer, mania, muscle spasm of varied aeitology, NSAID-associated gastric and duodenal ulcers.
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