How It Works:
Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.
Vomiting, Nausea, Nystagmus (involuntary eye movement), Abdominal pain, Coma, Apnea (absence of breathing), Altered heart rate, Vertigo, Balance disorder (loss of balance), Contact dermatitis, Drowsiness