How It Works:

Paliperidone belongs to a group of medications called atypical antipsychotics. It works by altering the activities of certain chemicals (neurotransmitters) in the brain thereby relieving the symptoms of schizophrenia.

Side Effects:

back pain, upper respiratory tract infection, arthralgia, dizziness, increased/ decreased appetite, fatigue., pruritus, akathisia, agitation, increase/ decrease in weight, conduction disorder, diarrhea, dry mouth, tachycardia, nausea, abdominal discomfort, nasal congestion, tremor, bradycardia, weakness, atrioventricular block, orthostatic hypotension, fever, Insomnia, vomiting, depression, sedation/ somnolence, influenza, musculoskeletal pain, dyskinesia, electrocardiogram abnormalities, parkinsonism, toothache, dystonia, transaminases increased, mania, cough, rash, hypertension, urinary tract infection, vision blurred, abdominal pain, pharyngolaryngeal pain, sinusitis, anxiety, headache, bronchitis, constipation, dyspepsia

Used For:

Paliperidone is used to treat symptoms of schizophrenia (a psychiatric disorder with symptoms of emotional instability, detachment from reality, often with delusions and hallucinations, and withdrawal into the self). It is also used for treating schizoaffective disorders (a mixed psychiatric disorder relating to a complex psychotic state that has features of both schizophrenia and a mood disorder such as bipolar disorder).


  • You can take paliperidone with or without breakfast, however, same pattern to be followed during the entire treatment.
  • Inform your doctor if you have known cardiovascular disease or family history of QT prolongation and if you are taking medicines that may prolong the QT interval.
  • Discontinue and inform you doctor immediately if you experience Neuroleptic Malignant Syndrome (NMS), characterised by hyperthermia (fever), muscle rigidity, autonomic instability, altered consciousness, and elevated serum creatine levels.
  • Inform your doctor if you have a swallowing, stomach or intestinal disorder that reduces your ability to swallow or pass foods by normal bowel movements.
  • You may suffer from tardive dyskinesia characterized by rhythmical, involuntary movements, predominantly of the tongue and/or face. Inform you doctor if you experience such symptoms.
  • You may suffer from priapism (prolonged and/or painful erection), inform your doctor if you experience such symptoms.
  • Do not drive or operate machinery as paliperidone may have some nervous effects and may cause visual disturbances. 
  • If you are a patient with diabetes, or with schizophrenia, taking paliperidone may increase the risk of developing diabetes. You should monitor glucose regularly while on paliperidone treatment.
  • Seek immediate medical attention if the thoughts of suicide occur when on paliperidone therapy.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently Ask Questions:

Q. Is paliperidone safe during pregnancy? Paliperidone should only be used during pregnancy if the potential benefits justify the potential risk to the baby. Please follow your doctor's advice regarding its use.   Q. Is it safe to use paliperidone during breastfeeding? It is not known whether paliperidone is excreted in human milk. Paliperidone should be given only if the potential benefit justifies the potential risk to the baby. Please follow your doctor's advice regarding its use.   Q. Is paliperidone the same as risperidone? Paliperidone gets converted to risperidone in the body and thus exerts similar actions.   Q. Is paliperidone a narcotic? No, paliperidone is not a narcotic.   Q. Is paliperidone an atypical antipsychotic? Yes, paliperidone is an atypical antipsychotic.   Q. How is paliperidone metabolized? Paliperidone is metabolized to its active metabolite risperidone by the CYP family of metabolizing enzymes.    Q. Does paliperidone cause weight gain? Yes, paliperidone is known to cause weight gain.   Q. Does paliperidone cause erectile dysfunction? Paliperidone may cause priapism (prolonged and/or painful erection), which may contribute to erectile dysfunction. Please follow your doctor's advice regarding its use.   Q. How long does paliperidone stay in your system? Oral paliperidone may take 5 days to clear off from your body/system, whereas the injection may take around 4 to 8 months to clear off from your body/system.
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