S-adenosyl Methionine

How It Works:

S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.

Side Effects:

Nausea, skin rash, stomach upset, acute toxicity.

Used For:

Used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis.
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