How It Works:
Trihexyphenidyl is an anticholinergic agent, which works by blocking the action of a chemical called acetylcholine on the nerves which results in relaxing of smooth muscles; thereby, reducing the rigidity of muscle spasm (sudden involuntary contraction of a muscle or group of muscles), tremor (uncontrolled shaking) and excessive salivation associated with Parkinson’s disease.
tachycardia, restlessness, blurring of vision, hallucination, nausea, impaired memory, euphoria, vomiting, confusion, difficulty urinating and rash., constipation, Dryness of mouth, dizziness, anxiety
Trihexyphenidyl is used to treat symptoms of Parkinson’s disease (a type of nerve disease that causes movement disorder characterized by slowness of movements, muscle stiffness, uncontrolled shaking and poor balance and co-ordination) and drug-induced extra pyramidal symptoms (movement disorders similar to symptoms of Parkinson’s disease) except tardive dyskinesia (involuntary movement of face and jaw). It is often given along with levodopa (anti-Parkinson drug).
- Trihexyphenidyl should be used cautiously in patients with high blood pressure (hypertension), heart, kidney or liver disorders, glaucoma (increase in pressure inside the eye causing gradual loss of vision if left untreated), obstructive disease of the digestive, genital and urinary tracts, myasthenia gravis (a disease characterized by very weak and unusually tired muscles) and in elderly men with enlarged prostate gland (prostatic hypertrophy).
- Seek immediate medical attention if you experience psychiatric symptoms such as – confusion, delusions (believing in things that are not real) and hallucinations (seeing or hearing things that that are not real). Extreme caution should be taken in elderly.
- Trihexyphenidyl is not recommended for use in patients with tardive dyskinesia (involuntary movement of face and jaw) and in children under 18 years of age.
- Trihexyphenidyl is not recommended as prophylaxis (preventive treatment) for drug-induced parkinsonism.
- Avoid abrupt discontinuation of treatment as it can result in worsening of symptoms of Parkinson’s disease or emergence of life-threatening complications (neuroleptic malignant syndrome).
- Take precautions while driving or operating machinery as trihexyphenidyl can impair mental and physical abilities.
- Use trihexyphenidyl with caution in hot weather as it can increase susceptibility to heat stroke (symptoms: very high fever, inability to bear heat, nausea, vomiting etc.)
- Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
Frequently Ask Questions:
Q. Is trihexyphenidyl safe during pregnancy?Trihexyphenidyl should be used during pregnancy only if clearly needed and if benefits outweigh potential risks. Please follow your doctor’s advice regarding use.
Q. Is trihexyphenidyl safe during breastfeeding?Trihexyphenidyl should be used cautiously in breastfeeding women. Please follow the advice of your doctor regarding use.
Q. Does trihexyphenidyl get you high/ cause weight gain?Trihexyphenidyl doesn’t make you feel high. It does not cause weight gain
Q. Does trihexyphenidyl work?Trihexyphenidyl works by blocking the action of a chemical called acetylcholine on the nerves which results in relaxing of smooth muscles; thereby, reducing the rigidity of muscle spasm (sudden involuntary contraction of a muscle or group of muscles), tremor (uncontrolled shaking) and excessive salivation associated with Parkinson’s disease.